Remark: Barbiturates could boost adverse effects, which include respiratory depression, made by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
People stabilized on corticosteroid therapy may possibly call for dosage changes if barbiturates are additional to or withdrawn from their dosage program as a result of induction of hepatic microsomal enzymes by barbiturates
pentobarbital will decrease the extent or impact of almotriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Monoamine oxidase inhibitors (MAOI) may possibly inhibit barbiturate metabolism and lengthen barbiturate effects; keep track of intently
pentobarbital will minimize the level or outcome of tolterodine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lower the extent or effect of nicardipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will lessen the extent or result of osilodrostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the extent or outcome of zonisamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
Contraindicated (one)pentobarbital will lessen the level more info or effect of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals should not choose estradiol valerate/dienogest as their contraceptive although employing solid CYP3A4 inducers as a result of possible lessen in contraceptive efficacy.
With therapeutic doses of TCAs, barbiturates improve metabolism and reduce blood concentrations of TCAs.
pentobarbital will decrease the extent or outcome of ziprasidone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.
With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
Check Intently (1)pentobarbital will increase the stage or result of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the extent or impact of ritonavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.